The strategic goals cut across the Institute’s heart, lung, blood, and sleep (HLBS) research portfolio and are rooted in a desire to understand and promote health and resilience, stimulate discoveries in the causes of disease, enable the translation of discoveries from basic research into clinical practice, and foster training and mentoring of emerging scientists and physicians.
The 4 Goals are:

  • Understand Human Biology
  • Reduce Human Disease
  • Advance Translational Research
  • Develop Workforces & Resources

Overarching Objectives
The eight objectives provide an organizing framework for the NHLBI Research Priorities. The objectives reflect one or more of the strategic goals. Over the next decade, these objectives will serve as the NHLBI’s guide for moving HLBS science forward, exploring research opportunities, and making investment decisions. While these objectives are not meant to embody the NHLBI’s entire research portfolio, the strategic research priorities corresponding to the objectives will play a substantial role in helping the NHLBI to set, and periodically refine, a research agenda  and priorities for the next decade.
1. Understand normal biological function and resilience
2. Investigate newly discovered pathobiological mechanisms important to the onset and progression of HLBS diseases
3. Investigate factors that account for differences in health among populations
4. Identify factors that account for individual differences in pathobiology and in responses to treatments
5. Develop and optimize novel diagnostic and therapeutic strategies to prevent, treat, and cure HLBS diseases
6. Optimize clinical and implementation research to improve health and reduce disease
7. Leverage emerging opportunities in data science to open new frontiers in HLBS research
8. Further develop, diversify, and sustain a scientific workforce capable of accomplishing the NHLBI’s mission



Academic health centers are uniquely situated to pursue the tri-partite mission of care, training and research, three components which are all essential for successfully addressing the short and long-term challenges of global health.
Training (nearly 1,200 Kenyan and American medical students have participated in the program and thousands of Kenyan health care providers have been trained by AMPATH) and research (AMPATH researchers have published over 450 articles and attracted over $100 million in cumulative funding for AMPATH-related research projects from NIH, Gates Foundation, and other sources) are critical components of that effort, and we are dedicated to leading with care.

This mission of care, research, and training is embraced by institutions like Brown University’s Alpert Medical School, Duke University, Icahn School of Medicine at Mount Sinai, Lehigh Valley Health Network, Providence Portland Medical Center, Purdue University, University of California-San Francisco, University of Massachusetts, University of Notre Dame, and University of Toronto who all have joined together with Indiana University as the AMPATH Consortium to partner with the Moi Hospital and University, allowing the Kenyan leaders to draw upon the resources and talents of North American academic health institutions to tackle the challenges of disease and poverty.