The strategic goals cut across the Institute’s heart, lung, blood, and sleep (HLBS) research portfolio and are rooted in a desire to understand and promote health and resilience, stimulate discoveries in the causes of disease, enable the translation of discoveries from basic research into clinical practice, and foster training and mentoring of emerging scientists and physicians.
The 4 Goals are:

  • Understand Human Biology
  • Reduce Human Disease
  • Advance Translational Research
  • Develop Workforces & Resources

Overarching Objectives
The eight objectives provide an organizing framework for the NHLBI Research Priorities. The objectives reflect one or more of the strategic goals. Over the next decade, these objectives will serve as the NHLBI’s guide for moving HLBS science forward, exploring research opportunities, and making investment decisions. While these objectives are not meant to embody the NHLBI’s entire research portfolio, the strategic research priorities corresponding to the objectives will play a substantial role in helping the NHLBI to set, and periodically refine, a research agenda  and priorities for the next decade.
1. Understand normal biological function and resilience
2. Investigate newly discovered pathobiological mechanisms important to the onset and progression of HLBS diseases
3. Investigate factors that account for differences in health among populations
4. Identify factors that account for individual differences in pathobiology and in responses to treatments
5. Develop and optimize novel diagnostic and therapeutic strategies to prevent, treat, and cure HLBS diseases
6. Optimize clinical and implementation research to improve health and reduce disease
7. Leverage emerging opportunities in data science to open new frontiers in HLBS research
8. Further develop, diversify, and sustain a scientific workforce capable of accomplishing the NHLBI’s mission